In 1964, a sister soap was created for General Hospital, The Young Marrieds it ran for two years, and was canceled because of low ratings. General Hospital was the second soap to air on ABC (after the short-lived Road to Reality, which aired for several months during the 1960–61 season). They were joined a year later by Rachel Ames who remains to date the longest serving actress on an ABC soap opera, having been continuously on the show from 1964 to 2007. From its beginning, General Hospital starred John Beradino and Emily McLaughlin, and both actors stayed with the show until their deaths in 19, respectively.

In the 1970s, the city was named Port Charles, New York. The show was created by husband-and-wife soap writers Frank and Doris Hursley, who originally set it in a hospital, in an unnamed fictional city. It holds the record for most Daytime Emmy Awards for Daytime Emmy Award for Outstanding Drama Series, with 14 wins. General Hospital is the longest-running serial produced in Hollywood, and the longest-running entertainment program in ABC television history. General Hospital premiered on the ABC television network on April 1, 1963. Concurrently, it is the world's third longest-running scripted drama series in production after British serials The Archers and Coronation Street, as well as the world's second-longest-running televised soap opera still in production. It is listed in Guinness World Records as the longest-running American soap opera in production, and the second in American history after Guiding Light. General Hospital (often abbreviated as GH) is an American daytime television soap opera.

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